TC297

University of Oxford - Studies on Nucleophilic Cysteine Enzymes Involved in Bacterial Cell Wall Biosynthesis- iCASE

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Principal Investigator (PI)

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Project location

the sponsor

Home Institution

Oxford University

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foundation funding

Foundation funding

The Foundation is providing £28,674.000 in support.

Open Labs Fellow/s

Mariska de Munnik

Project Participant

Mariska de Munnik

GSK’s contribution

The origination of this project has benefitted greatly through the collaboration with GSK R&D to date (p

Project Description

Publications 3

Chemical communications (Cambridge, England), 59(86)

aß,a'ß'-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes

de Munnik, M., Lithgow, J., Brewitz, L., Christensen, K. E., Bates, R. H., Rodriguez-Miquel, B., & Schofield, C. J.

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Chemical science, 14(26)

High-throughput screen with the l,d-transpeptidase LdtMt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors

de Munnik, M., Lang, P. A., De Dios Anton, F., Cacho, M., Bates, R. H., Brem, J., Rodríguez Miquel, B., & Schofield, C. J.

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Antimicrobial agents and chemotherapy, 69(10)

Targeting mycobacterial transpeptidases: evaluating the roles of Ldt and PBP inhibition in suppressing Mycobacterium smegmatis

de Munnik, M., Calvopiña, K., Rabe, P., & Schofield, C. J.

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